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KMID : 0362220110380010025
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Journal of The Korean Research Society for Dental Materials
2011 Volume.38 No. 1 p.25 ~ p.32
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Cytotoxicity Evaluation of Titanium Surface Coated Bisphosphonate
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Kang MIn-Kyung
Moon Seung-Kyun
Kim Kwang-Man
Kim Kyoung-Nam
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Abstract
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The aim of this study was to evaluate cytotoxicity of bisphosphonate coated titanium. To coat the bisphosphonate on the titanium, the titanium was modified by anodization and heat-treatment. Then, a biomimetic coating process was completed in two steps. Surface characterization was performed with scanning electron microscopy, energy dispersive spectroscopy, and X-ray Photoelectron spectroscopy. Cytotoxicity was evaluated by MTT assay. After the second coating step, we found that the modified titaniums were formed thick and homogeneous apatite layer that contained the bisphosphonate. Modified titanium were increased the loading of calcium and phosphate ion onto the surface. However, bisphosphonate coated titanium had more cytotoxicity as the concentration of bisphosphonate on the surface was increased. Therefore, these results suggested that further study should be done to demonstrate the effect and safety of this material at the different drug concentration.
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KEYWORD
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Anodic oxidation, Biomimetic coating, Bisphosphonate, Cytotoxicity, Heat-treatment
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